Chemical constituants of nirgundi - Vitex negundo Linn.

nirgundi :

nirgundi : Vitex negundo Linn.

Phytochemistry:

 Leaves 

6′-p-hydroxybenzoyl mussaenosidic acid; 2′-p-hydroxybenzoyl mussaenosidic acid viridiflorol; β-caryophyllene; sabinene; 4-terpineol; gamma-terpinene; caryophyllene oxide; 1-oceten-3-ol; globulol; 5,3′-dihydroxy-7,8,4′- trimethoxyflavanone; 5,3′-dihydroxy,6,7,4′trimethoxyflavanone; 5-hydroxy-3,6,7,3,4-pentamethoxy flavones; 5,7dihydroxy-6,4 dimethoxy flavonone; 5hydroxy-7,4 dimethoxy flavones; 5,3-dihydroxy-7,8,4-trimethoxy flavanone; betulinic acid [3β-hydroxylup-20-(29)-en-28-oic acid]; ursolic acid [2β -hydroxyurs-12-en-28-oic acid]; n-hentriacontanol; β-sitosterol; p-hydroxybenzoic acid; protocatechuic acid; oleanolic acid; flavonoids angusid; casticin; vitamin-C; nishindine; gluco-nonitol; 


Seeds 

3β-acetoxyolean-12-en-27-oic acid; 2α, 3α-dihydroxyoleana-5,12-dien-28-oic acid; 2β,3α diacetoxyoleana-5,12- dien-28-oic acid; 2α, 3β-diacetoxy-18-hydroxyoleana-5,12-dien-28-oic acid; vitedoin-A; vitedoin-B; a phenylnaphthalene-type lignan alkaloid, vitedoamine-A; five other lignan derivatives, 6-hydroxy-4-(4-hydroxy-3- methoxy-phenyl)-3-hydroxymethyl-7-methoxy-3,4-dihydro-2-naphthaldehyde, β-sitosterol; p-hydroxybenzoic acid; 5-oxyisophthalic acid; n-tritriacontane, n-hentriacontane; n-pentatriacontane; n-nonacosane. 

Roots

 2β,3α-diacetoxyoleana-5,12-dien-28-oic acid; 2α,3α-dihydroxyoleana-5,12-dien-28-oic acid; 2α,3β-diacetoxy-18- hydroxyoleana-5,12-dien-28-oic acid; vitexin; isovitexin, negundin-A; negundin-B; (+)-diasyringaresinol; (+)- lyoniresinol; vitrofolal-E; vitrofolal-F, acetyl oleanolic acid; sitosterol; 3-formyl-4.5-dimethyl-8- oxo-5H-6,7- dihydronaphtho (2,3-b)furan. 

Essential oil of fresh leaves, flowers and dried fruits 

δ-guaiene; guaia-3,7-dienecaryophyllene epoxide; ethyl-hexadecenoate; α-selinene; germacren-4-ol; caryophyllene epoxide; (E)-nerolidol; β-selinene; α-cedrene; germacrene D; hexadecanoic acid; p-cymene and valencene. viridiflorol (19.55%), β-caryophyllene (16.59%), sabinene (12.07%), 4-terpineol (9.65%), γ-terpinene (2.21%), caryophyllene oxide (1.75%), 1-oceten-3-ol (1.59%), and globulol (1.05%). Viridiflorol


PHARMACOLOGY:

anti-inflammatory, 
anti-rheumatic, 
antibiotic, 
hepatoprotective,
antioxidant, 
anticonvulsant, 
oxidative stress, 
anti-androgen, 
snake venome neutralization and 
anti-allergic activities


Dr Mohamed Rifas

A dual country licensed Ayurveda Physician, currently working in Dubai as Head of Ayurveda and Yoga department. He also works as visiting doctor for Dr Hassan Ayurveda Brain and Spine Specialty Hospital. He is specialized in joint issues, brain and spine related issues and gastrointestinal issues with respect to anxiety.
Doctor profile: Click here

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