nirgundi :

Precautions:

Nirgundi should be used with caution with the concurrent use of psychotropic drugs, including analgesics, sedatives, antidepressants, anticonvulsants and antipsychotics. Vitex negundo Linn. is quite similar botanically to the better studied Vitex agnus castus, and thus may have a similar range of contraindications, including the concurrent use of progesterogenic drugs and hormone replacement therapies8 .

Toxicity studies:

Preliminary acute toxicity study of ethanolic leaf extract in albino rats by oral route carried out by Tandon and Gupta 2004) indicated it to be practically nontoxic, as its LD50 dose recorded was 7.5 g/kg/wt. The stomach showed no histomorphological changes in any of the doses of theextract studied. However, dose dependent histomorphological changes were observed in the specimens of the heart, liver and lung

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