sthulgokshura :

Toxicity studies:

The acute toxicity studies of the P. murex plant were reported to be safe up to the dose level of 2 260 mg/kg, p.o. in mice. The study were performed on the male Swiss albino mice (20-25 g) which was orally administered with ethanolic extract of P. murex and observed for any symptoms of toxicity for 48 h as per CPCSEA guidelines. LD50 were estimated by Karber’s method and were reported to be 2 260 mg/kg, p.o. Based on these results, the dosages for further pharmacological study were fixed at 250 mg/kg, p.o.[54]. Administration of alcoholic extracts of P. murex orally to male Swiss albino mice produced no observable side effects up to 2 260 mg/kg, p.o. body weight even after 48 h of observation[9]. An acute toxicity study of P. murex mucilage showed no manifestations of toxic syndromes and has been found to be safe. (LD50 > 2 000 mg /kg)[

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