nandivriksha :

Phytochemistry:

Roots contain resin, extractive matter and a bitter alkaloid.

- The milky juice contains caoutchouc and resin.

- Studies have yielded alkaloids and non-alkaloid constituents, flavonoids, phenyl propanoids, phenolic acids and enzymes.

- Phytochemical screening of an ethanol extract yielded steroids, tannins, saponins, gums and reducing sugar.

- Phytochemical screening of hydroalcoholic and aqueous extracts of leaves yielded the presence of alkaloids, tannins, resins, proteins, amino acids, flavonoids, saponins, phenols, glycosides, steroids, triterpenoids, fixed oils, and fats.

Study of ethanol, acetone, and water extracts for amino acids yielded 2-aminobutyric acid (E,W), proline (A,W), cysteine hydrochloride (W), leucine and iso-leucine (W).

- Phytochemical screening of ethyl acetate and methanol extract of leaves yielded alkaloids, flavonoids, carbohydrates, phenolic compounds, glycosides and tannins. Petroleum ether and chloroform extracts yielded steroids and triterpenes.

• Study of branches and leaves yielded three new monoterpene indole alkaloids: 3α-hydroxymethyl-ibogamine (1), 3α-acetatemethoxyl-ibogamine (2), 16α-hydroxyl-ibogamine (3) along with six known alkaloids

PHARMACOLOGY:

Important formulations:

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