Its use in children or in physically or mentally weaker persons or overdose of Operculina turpethum may lead to complications like excessive purgative activity, bleeding per rectum, vomiting, abdominal pain, chest pain, dehydration, hypotension, vertigo, confusion, shock, & unconsciousness.

It  should not be used in pregnancy, in children below 12 years of age, in elderly, in physically or mentally weaker persons, and in persons suffering from diarrheoa, bleeding per rectum, rectal prolapse, or fecal incontinence.

Trivrit may act as an abortificient when used in pregnant ladies.

In an acute toxicity study (Rajashekar M et al; 2006), healthy albino mice of either sex were  divided into eight different groups of six animals each. Animals of the group 1 received acacia suspension (0.5 ml orally) while the animals of group 2 to 8 received suspension of root of O. turpethum at 10, 30, 100, 200, 400, 600, 800 mg/kg dose levels respectively. The animals were observed at 0, ½, 1, 2 and 4 hours after the administration for acute effect and mortality. The observation was continued for one week for the delayed effects and mortality. Results revealed that there were no treatment related deaths or any toxic effects in any of the groups.

In another acute toxicity study (S. V. Suresh Kumar et al; 2006), an ethanolic extract of O.turpethum, when administered in different groups of Wistar rats of either sex in doses ranging from 100-2000 mg/kg, produced no lethality in any of the groups. Also the extract did

not produce any alterations in liver function markers like SGOT, SGPT, serum alkaline phosphatage and serum bilirubin.