Madumeha  is a general systemic disease caused by the derangement of tridoshas and manifest through the symptomsof urinary system. Diabetes can be included under the broad concept of Madumeha . The estimate of the actual numberof diabetics in India is around 40 million, which causes a major health concern.  Acharya Susrutha  has mentioned two rasayana  in Madhumeha cikitsa . They are Shilajatu  and Makshika rasayana . Both these are having Tridoshashamana, Agnideepana, Medohara, Balya, Cakshushya, Vrishya  and Yogavahiproperty. These minerals are richest source of manymicronutrients Diabetes mellitus and vice versa can disrupt homeostasis of trace elements. The alteration of metalsstatus increase oxidative stress that may contribute to the insulin resistance and development of diabeticcomplications. Thorough analysis of Ayurvedic concepts and modern research works carried out reveal that, Swarna Makshika  and Shilajatu  definitely play a role in glucose and insulin metabolism.

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