Quantitative determination of major phytocompounds in ethanolic extract of Cassia auriculata (CA) flowers showed that the flavonoid, phenol and alkaloid content in 100g of flower as 21.1g, 9.2g and

6.66g respectively. 

Serum levels of Glucose, c-peptide, and liver marker enzymes and liver glycogen levels.

The diabetic group showed significant increase in blood glucose levels when compared to control group (P≤0.05).

On the other hand, treatment with CAÉ caused significant reduction in the glucose levels at both the concentrations used in this study (Fig 1). CAÉ at the dose of 500mg/Kg b.w produced well pronounced

hypoglycemic effect by restoring the glucose levels to normal range and its effect was comparable to that caused by the standard hypoglycemic agent-glibenclamide used in this study. Serum Cpeptide levels showed significant reduction (P≤0.05) in diabetic group while the treated groups showed significant elevation in cpeptide levels confirming the antidiabetic potential of Cassia auriculata flowers. Glibenclamide also produced a similar positive effect. The serum levels of liver marker enzymes alanine transaminase (SGPT), aspartate transaminase (SGOT) and alkaline phosphatase (ALP) were also significantly elevated in diabetic group as compared to control indicating diabetes associated liver damage. The total liver glycogen content also was found to be significantly decreased in diabetic group when compared to control group. Grippingly, treatment with CAE regulated the levels of liver marker enzymes and caused significant increase (P≤0.05) in glycogen levels